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| Our expertise in immunology permits the rapid evaluation of immune modulation by therapeutics targeted at infectious disease or cancer. Our assays will evaluate the functionality of various components of the immune system and determination of the effects of therapeutic intervention on the ability of the immune system to respond effectively to infection. Our immunology expertise also facilitates the development of novel immunoassays to probe and analyze therapeutic strategies.
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Immune function evaluation, including humoral, cellular and innate immunity |
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Immunoassay development for antigenicity and neutralization evaluations |
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ELISPOT and cytokine quantification |
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Flow cytometry |
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Clinical trial support |
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| Immunoassay Development and Validation for Advanced Therapeutic Protein Development |
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Bioanalytical Immunoassay Development Services: We can quantify your protein or peptide in biological matrices using ELISA in support of safety assessment and clinical trial programs. |
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Therapeutic Protein Immunogenicity: We can develop, optimize and perform cell-based and/or biochemical immunoassays to quantify the immunogenicity of your protein and to determine if the immunogenicity leads to the generation of neutralizing antibodies. |
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Protein Analytical Services: Our Protein Biochemistry group will develop the necessary methods to analyze your protein or peptide, including analysis of the purity and identity of your protein (1D and 2D SDS-PAGE, IEF, chromatofocusing, FPLC/HPLC, Western blotting, ELISA); preformulation and protein stability studies (pH and ionic strength, buffer and excipient compatibility, forced degradation and stability); activity analyses using bio- or enzymatic assays (cell- or non-cell based); and other biochemical and biophysical analyses. |
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Polyclonal and Monoclonal Antibody Services: The development of immunoassays requires the development of high titer antibodies for assay development. We can assist in the development of these crucial reagents. |
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Customized Assay Development, Optimization and GLP-Validation: Independent quality assurance unit to audit the validation and performance of the GLP-compliant immuno assays necessary for the development of your therapeutic protein, peptide, antibody, or biologic product. Make ImQuest your one stop for assay development to solve your therapeutic development needs, from discovery through clinical trials. |
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Protein Therapeutic Support: ImQuest can support the development of your protein drug from discovery to the late stage preclinical phase, aiding in project progression and IND submission using ICH Guidelines and FDA Points to Consider. |
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| ImQuest BioSciences has a proven track record of providing support to effectively move compounds from the discovery phase to preclinical IND-enabling studies for human clinical trials. Our expertise in infectious disease, cancer, immunology, and inflammatory disease is deeply founded in our core scientific capabilities in microbiology, cell biology, molecular biology, protein production, biochemistry, and enzymology. |
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| Copyright © 2010, ImQuest BioSciences. | | | |
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